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SCIENTIFIC JOURNALS
of Republic of India
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Country

Vol 1, No 3 (2010)
by 31st of December, 2010

Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review

Abstract in English

Studies of drug-excipient compatibility represent an important phase in the pre-formulation stage for the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature, the stability and bioavailability of drugs and, consequently, their therapeutic efficacy and safety. The present review covers the literature reports of incompatibilities of commonly used pharmaceutical excipients with different active pharmaceutical ingredients. Examples of drug-excipient interactions, such as transacylation, the Maillard browning reaction, acid base reactions and physical changes are discussed for different active pharmaceutical ingredients belonging to different therapeutic areas viz. antiviral, anti-inflammatory, antidiabetic, antihypertensives, CNS drugs, anti-convulsants, antibiotics, bronchodialators, antimalarial, amtiemetic, vitamins, antiamoebics, antipsychotics, antidepressants, anticancer, anticoagulants and sedatives/ hypnotics. Once solid-state reactions are understood in a pharmaceutical system, the necessary steps can be taken to prevent reactivity and improve the stability of drug substances and products.

Language
English
Subject

Incompatibility, interaction, active pharmaceutical ingredient, excipients, lactose, magnesium stearate

Type
Reviews
Firstpage Number
3-26
Keywords

Incompatibility, interaction, active pharmaceutical ingredient, excipients, lactose, magnesium stearate

Date of issue
Volume
1
Issue
3
Category
Cite
MIA

Sonali S. Bharate, et al. "Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review" Journal of Excipients and Food Chemicals 1.3 (2010): 3-26.


Harvard

Sonali S. Bharate, Sandip B. Bharate, Amrita N Bajaj, 2010. Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review. Journal of Excipients and Food Chemicals, 1(3), pp.3-26.


Chicago

Sonali S. Bharate, Sandip B. Bharate, Amrita N Bajaj. "Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review." Journal of Excipients and Food Chemicals 1, no. 3 (2010): 3-26.


ДСТУ 2006

Sonali S. Bharate, Sandip B. Bharate, Amrita N Bajaj. Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review / Sonali S. Bharate, Sandip B. Bharate, Amrita N Bajaj // Journal of Excipients and Food Chemicals. - 2010. Vol. 1. - № 3. - pp. 3-26.


ГОСТ 2008

Sonali S. Bharate, Sandip B. Bharate, Amrita N Bajaj. Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review // Journal of Excipients and Food Chemicals. 2010. № 3 (1). С. 3-26.


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